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PERSONAL INFORMATION

Important Safety Information

PROLENSA^® contains sodium sulfite, a sulfite that may cause allergic type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. The overall prevalence of sulfite sensitivity in the general population is unknown and probably low. Sulfite sensitivity is seen more frequently in asthmatic than in non-asthmatic people.

All topical nonsteroidal anti-inflammatory drugs (NSAIDs), including bromfenac, may slow or delay healing. Concomitant use of topical NSAIDs and topical steroids may increase the potential for healing problems.

There is the potential for cross-sensitivity to acetylsalicylic acid, phenylacetic acid derivatives, and other NSAIDs, including bromfenac. Use with caution in patients who have previously exhibited sensitivities to these drugs.

There have been reports that ocularly applied NSAIDs may cause increased bleeding of ocular tissues (including hyphemas) in conjunction with ocular surgery. Use with caution in patients with known bleeding tendencies or who are receiving other medications which may prolong bleeding time.

Use of topical NSAIDs may result in keratitis. Patients with evidence of corneal epithelial breakdown should immediately discontinue use of topical NSAIDs, including bromfenac, and should be closely monitored for corneal health. Patients with complicated ocular surgeries, corneal denervation, corneal epithelial defects, diabetes mellitus, ocular surface diseases (e.g., dry eye syndrome), rheumatoid arthritis, or repeat ocular surgeries within a short period of time may be at increased risk for corneal adverse events which may become sight threatening. Topical NSAIDs should be used with caution in these patients. Post-marketing experience with topical NSAIDs suggests that use more than 24 hours prior to surgery or use beyond 14 days post-surgery may increase patient risk for the occurrence and severity of corneal adverse events.

Do not touch dropper tip to the eye, eyelids, or to any surface, as this may contaminate the contents. Replace the bottle cap after using.

PROLENSA^® should not be instilled while wearing contact lenses. The preservative in PROLENSA^®, benzalkonium chloride, may be absorbed by soft contact lenses. Lenses may be reinserted after 10 minutes following administration of PROLENSA^®.

The most commonly reported adverse reactions in 3%-8% of patients were anterior chamber inflammation, foreign body sensation, eye pain, photophobia, and blurred vision.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Clickhere for full Prescribing Information for PROLENSA^®.

DELIVER THE PROLENSA^® EFFECT^1-3

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FOR PENETRATION^1,2

DESIGNED WITH
COMFORT IN MIND^1,2

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PERSONAL INFORMATION

Indication and Important Safety Information

Indications and usage

Important Safety Information

Indications and usage

DELIVER THE PROLENSA® EFFECT1-3

POWERED FOR PENETRATION1,2

DESIGNED WITHCOMFORT IN MIND1,2

DELIVER THE PROLENSA® EFFECT1-3

PERSONAL INFORMATION

Indication and Important Safety Information

Indications and usage

Important Safety Information

DELIVER THE PROLENSA^® EFFECT^1-3

POWERED
FOR PENETRATION^1,2

DESIGNED WITH
COMFORT IN MIND^1,2

DELIVER THE PROLENSA^® EFFECT^1-3